![]() ![]() 1 Multivitamins typically contain about 400 IU/d consumption of 1000 IU or more daily likely indicates intentionally seeking supplemental vitamin D. ![]() The tolerable upper limit is 4000 IU/d beyond this level risk of toxic effects increases. The recommended dietary allowance for vitamin D is 600 IU/d for adults 70 years or younger and 800 IU/d for those older than 70 years. 2 The IOM report noted possible harm (eg, hypercalcemia, soft tissue or vascular calcification) for intakes above the tolerable upper limit, which is the highest level of intake likely to pose no risk of adverse effects for most adults. 1 Several large-scale trials are ongoing to evaluate the effect of vitamin D supplementation on extraskeletal outcomes. However, a 2011 Institute of Medicine (IOM now the National Academy of Medicine) report concluded that vitamin D was beneficial for bone health but evidence was insufficient for extraskeletal health. Since 2000, there has been an increase in research on possible health benefits of vitamin D. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography. ![]()
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